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Ranked #194 by analyst upside · 2026-06-27
UPB
Upstream Bio, Inc.
Healthcare · Market Cap $367M · P/E 0x
ANALYST PRICE TARGET
+466.7%
implied upside to consensus target
Current Price $6.75
Consensus Target $38.25
Bull Target $75.0
Bear Target $8.0
Analysts Covering 8
ANALYST CONSENSUS — BUY
Strong Buy
2
Buy
5
Hold
1
Sell
0
52-Week Low $5.85
52-Week High $33.68
YTD Return -75.1%
FUNDAMENTALS
Market Cap $367M
P/E Ratio (TTM) N/A
Forward P/E -2.3x
EPS (TTM) $-3.08
PEG Ratio N/A
Dividend Yield N/A
Revenue (TTM) $3M
Profit Margin N/A
52-WEEK RANGE
52-Week Low $5.85
52-Week High $33.68
Current Price $6.75
Bear Target $8.0
Bull Target $75.0
● Now $6.75 ● Target $38.25
TRADING DATA
Avg Volume 616K
YTD Return -75.1%
Analyst Count 8
Consensus Buy
Upside to Target +466.7%
Last Updated 2026-06-27

ANALYST SUMMARY

Upstream Bio, Inc. (UPB) is currently trading at $6.75 with a Wall Street consensus price target of $38.25, implying potential upside of 466.7% over the next 12 months. 8 analysts currently cover UPB, with a consensus rating of Buy — 88% of analysts rate the stock a Buy or Strong Buy. The most bullish analyst has a price target of $75.0, while the most cautious has a target of $8.0.

UPB operates in the Healthcare sector with a market capitalisation of $367M. The stock is down 75.1% year-to-date and is currently trading near the lower end of its 52-week range of $5.85 – $33.68.

SIMILAR STOCKS

Other Healthcare stocks with comparable size and valuation.

RECENT ANALYST CALLS

Upgrade/downgrade history for UPB, with each firm's 90-day track record across all stocks we track. See full firm rankings →

JP Morgan ↓ Downgrade
Overweight → Neutral 2026-06-12 43% win rate (7 calls)
HC Wainwright & Co. ● Initiated
Buy 2026-06-03 31% win rate (48 calls)
Mizuho — Reiterated
Outperform → Outperform 2026-05-14 Building track record
Evercore ISI Group ↓ Downgrade
Outperform → In-Line 2026-03-27 Building track record
Mizuho ● Initiated
Outperform 2025-12-18 Building track record
LifeSci Capital ● Initiated
Outperform 2025-12-02 Building track record
Evercore ISI Group ● Initiated
Outperform 2025-11-18 Building track record
Truist Securities ● Initiated
Buy 2025-10-14 Building track record
HISTORICAL SNAPSHOT

Point-in-time data from StockUpside's daily snapshots. Tracks price, analyst target, upside %, consensus, and analyst count.

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ANALYST CONVICTION SCORE
out of 100
Coverage depth
0/30
Consensus clarity
0/30
Vote unanimity
0/25
Rating stability
0/15

Measures analyst agreement, not fundamental quality. A high score means analysts broadly agree on this call — not that the stock will go up.

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