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Ranked #210 by analyst upside · 2026-09-28
UPB
Upstream Bio, Inc.
Healthcare · Market Cap $294M · P/E 0x
ANALYST PRICE TARGET
+481.0%
implied upside to consensus target
Current Price $5.36
Consensus Target $31.14
Bull Target $75.0
Bear Target $9.0
Analysts Covering 7
ANALYST CONSENSUS - BUY
Strong Buy
1
Buy
4
Hold
2
Sell
0
52-Week Low $4.99
52-Week High $33.68
YTD Return -80.2%
FUNDAMENTALS
Market Cap $294M
P/E Ratio (TTM) N/A
Forward P/E N/A
EPS (TTM) $-2.88
PEG Ratio N/A
Dividend Yield N/A
Revenue (TTM) $3M
Profit Margin N/A
52-WEEK RANGE
52-Week Low $4.99
52-Week High $33.68
Current Price $5.36
Bear Target $9.0
Bull Target $75.0
● Now $5.36 ● Target $31.14
TRADING DATA
Avg Volume 571K
YTD Return -80.2%
Analyst Count 7
Consensus Buy
Upside to Target +481.0%
Last Updated 2026-09-28

ANALYST SUMMARY

Upstream Bio, Inc. (UPB) is currently trading at $5.36 with a Wall Street consensus price target of $31.14, implying potential upside of 481.0% over the next 12 months. 7 analysts currently cover UPB, with a consensus rating of Buy - 71% of analysts rate the stock a Buy or Strong Buy. The most bullish analyst has a price target of $75.0, while the most cautious has a target of $9.0.

UPB operates in the Healthcare sector with a market capitalisation of $294M. The stock is down 80.2% year-to-date and is currently trading near the lower end of its 52-week range of $4.99 – $33.68.

SIMILAR STOCKS

Other Healthcare stocks with comparable size and valuation.

RECENT ANALYST CALLS

Upgrade/downgrade history for UPB, with each firm's 90-day track record across all stocks we track. See full firm rankings →

HC Wainwright & Co. reit
Buy → Buy 2026-09-02 31% win rate (48 calls)
JP Morgan - Reiterated
Neutral → Neutral 2026-08-14 43% win rate (7 calls)
Truist Securities - Reiterated
Buy → Buy 2026-08-12 Building track record
JP Morgan ↓ Downgrade
Overweight → Neutral 2026-06-12 43% win rate (7 calls)
HC Wainwright & Co. ● Initiated
Buy 2026-06-03 31% win rate (48 calls)
Mizuho - Reiterated
Outperform → Outperform 2026-05-14 Building track record
Evercore ISI Group ↓ Downgrade
Outperform → In-Line 2026-03-27 Building track record
Mizuho ● Initiated
Outperform 2025-12-18 Building track record
HISTORICAL SNAPSHOT

Point-in-time data from StockUpside's daily snapshots. Tracks price, analyst target, upside %, consensus, and analyst count.

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ANALYST CONVICTION SCORE
30
out of 100
Coverage depth
16/30
Consensus clarity
0/30
Vote unanimity
12/25
Rating stability
2/15

Measures analyst agreement, not fundamental quality. A high score means analysts broadly agree on this call - not that the stock will go up.

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