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Ranked #1907 by analyst upside · 2026-09-27
SYRE
Spyre Therapeutics, Inc.
Healthcare · Market Cap $8B · P/E 0x
ANALYST PRICE TARGET
+40.1%
implied upside to consensus target
Current Price $85.69
Consensus Target $120.08
Bull Target $130.0
Bear Target $97.0
Analysts Covering 13
ANALYST CONSENSUS - BUY
Strong Buy
0
Buy
12
Hold
1
Sell
0
52-Week Low $15.49
52-Week High $110.17
YTD Return +180.2%
FUNDAMENTALS
Market Cap $8B
P/E Ratio (TTM) N/A
Forward P/E N/A
EPS (TTM) $-1.92
PEG Ratio N/A
Dividend Yield N/A
Revenue (TTM) N/A
Profit Margin N/A
52-WEEK RANGE
52-Week Low $15.49
52-Week High $110.17
Current Price $85.69
Bear Target $97.0
Bull Target $130.0
● Now $85.69 ● Target $120.08
TRADING DATA
Avg Volume 1.2M
YTD Return +180.2%
Analyst Count 13
Consensus Buy
Upside to Target +40.1%
Last Updated 2026-09-27

ANALYST SUMMARY

Spyre Therapeutics, Inc. (SYRE) is currently trading at $85.69 with a Wall Street consensus price target of $120.08, implying potential upside of 40.1% over the next 12 months. 13 analysts currently cover SYRE, with a consensus rating of Buy - 92% of analysts rate the stock a Buy or Strong Buy. The most bullish analyst has a price target of $130.0, while the most cautious has a target of $97.0.

SYRE operates in the Healthcare sector with a market capitalisation of $8B. The stock is up 180.2% year-to-date and is currently trading near the upper end of its 52-week range of $15.49 – $110.17.

SIMILAR STOCKS

Other Healthcare stocks with comparable size and valuation.

RECENT ANALYST CALLS

Upgrade/downgrade history for SYRE, with each firm's 90-day track record across all stocks we track. See full firm rankings →

Wedbush reit
Outperform → Outperform 2026-09-09 Building track record
BTIG reit
Buy → Buy 2026-09-08 38% win rate (8 calls)
Deutsche Bank - Reiterated
Buy → Buy 2026-08-26 Building track record
Wedbush - Reiterated
Outperform → Outperform 2026-08-26 Building track record
BTIG - Reiterated
Buy → Buy 2026-08-26 38% win rate (8 calls)
BTIG - Reiterated
Buy → Buy 2026-08-11 38% win rate (8 calls)
Wells Fargo - Reiterated
Overweight → Overweight 2026-08-05 Building track record
Guggenheim - Reiterated
Buy → Buy 2026-08-05 62% win rate (8 calls)
HISTORICAL SNAPSHOT

Point-in-time data from StockUpside's daily snapshots. Tracks price, analyst target, upside %, consensus, and analyst count.

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ANALYST CONVICTION SCORE
64
out of 100
Coverage depth
20/30
Consensus clarity
22/30
Vote unanimity
20/25
Rating stability
2/15

Measures analyst agreement, not fundamental quality. A high score means analysts broadly agree on this call - not that the stock will go up.

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