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Ranked #2525 by analyst upside · 2026-08-13
SYRE
Spyre Therapeutics, Inc.
Healthcare · Market Cap $9B · P/E 0x
ANALYST PRICE TARGET
+17.3%
implied upside to consensus target
Current Price $104.09
Consensus Target $122.14
Bull Target $135.0
Bear Target $97.0
Analysts Covering 14
ANALYST CONSENSUS - BUY
Strong Buy
0
Buy
13
Hold
1
Sell
0
52-Week Low $14.51
52-Week High $108.14
YTD Return +240.4%
FUNDAMENTALS
Market Cap $9B
P/E Ratio (TTM) N/A
Forward P/E N/A
EPS (TTM) $-1.95
PEG Ratio N/A
Dividend Yield N/A
Revenue (TTM) N/A
Profit Margin N/A
52-WEEK RANGE
52-Week Low $14.51
52-Week High $108.14
Current Price $104.09
Bear Target $97.0
Bull Target $135.0
● Now $104.09 ● Target $122.14
TRADING DATA
Avg Volume 1.3M
YTD Return +240.4%
Analyst Count 14
Consensus Buy
Upside to Target +17.3%
Last Updated 2026-08-13

ANALYST SUMMARY

Spyre Therapeutics, Inc. (SYRE) is currently trading at $104.09 with a Wall Street consensus price target of $122.14, implying potential upside of 17.3% over the next 12 months. 14 analysts currently cover SYRE, with a consensus rating of Buy - 93% of analysts rate the stock a Buy or Strong Buy. The most bullish analyst has a price target of $135.0, while the most cautious has a target of $97.0.

SYRE operates in the Healthcare sector with a market capitalisation of $9B. The stock is up 240.4% year-to-date and is currently trading near the upper end of its 52-week range of $14.51 – $108.14.

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RECENT ANALYST CALLS

Upgrade/downgrade history for SYRE, with each firm's 90-day track record across all stocks we track. See full firm rankings →

BTIG - Reiterated
Buy → Buy 2026-06-15 38% win rate (8 calls)
Deutsche Bank - Reiterated
Buy → Buy 2026-06-04 Building track record
Citigroup - Reiterated
Buy → Buy 2026-05-06 Building track record
Stifel - Reiterated
Buy → Buy 2026-05-06 Building track record
Jones Trading - Reiterated
Buy → Buy 2026-04-17 57% win rate (14 calls)
Wells Fargo - Reiterated
Overweight → Overweight 2026-04-14 Building track record
Wedbush - Reiterated
Outperform → Outperform 2026-04-14 Building track record
Baird - Reiterated
Outperform → Outperform 2026-04-14 Building track record
HISTORICAL SNAPSHOT

Point-in-time data from StockUpside's daily snapshots. Tracks price, analyst target, upside %, consensus, and analyst count.

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ANALYST CONVICTION SCORE
66
out of 100
Coverage depth
21/30
Consensus clarity
23/30
Vote unanimity
20/25
Rating stability
2/15

Measures analyst agreement, not fundamental quality. A high score means analysts broadly agree on this call - not that the stock will go up.

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