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Ranked #1946 by analyst upside · 2026-11-14
SEPN
Septerna, Inc.
Healthcare · Market Cap $2B · P/E 0x
ANALYST PRICE TARGET
+39.0%
implied upside to consensus target
Current Price $42.6
Consensus Target $59.22
Bull Target $65.0
Bear Target $48.0
Analysts Covering 9
ANALYST CONSENSUS - BUY
Strong Buy
1
Buy
8
Hold
0
Sell
0
52-Week Low $19.69
52-Week High $53.34
YTD Return +52.3%
FUNDAMENTALS
Market Cap $2B
P/E Ratio (TTM) N/A
Forward P/E N/A
EPS (TTM) $-1.32
PEG Ratio N/A
Dividend Yield N/A
Revenue (TTM) $96M
Profit Margin -61.3%
52-WEEK RANGE
52-Week Low $19.69
52-Week High $53.34
Current Price $42.6
Bear Target $48.0
Bull Target $65.0
● Now $42.6 ● Target $59.22
TRADING DATA
Avg Volume 394K
YTD Return +52.3%
Analyst Count 9
Consensus Buy
Upside to Target +39.0%
Last Updated 2026-11-14

ANALYST SUMMARY

Septerna, Inc. (SEPN) is currently trading at $42.6 with a Wall Street consensus price target of $59.22, implying potential upside of 39.0% over the next 12 months. 9 analysts currently cover SEPN, with a consensus rating of Buy - 100% of analysts rate the stock a Buy or Strong Buy. The most bullish analyst has a price target of $65.0, while the most cautious has a target of $48.0.

SEPN operates in the Healthcare sector with a market capitalisation of $2B. The stock is up 52.3% year-to-date and is currently trading near the upper end of its 52-week range of $19.69 – $53.34.

SIMILAR STOCKS

Other Healthcare stocks with comparable size and valuation.

RECENT ANALYST CALLS

Upgrade/downgrade history for SEPN, with each firm's 90-day track record across all stocks we track. See full firm rankings →

Guggenheim - Reiterated
Buy → Buy 2026-11-06 62% win rate (8 calls)
Wells Fargo - Reiterated
Overweight → Overweight 2026-11-04 Building track record
JP Morgan - Reiterated
Overweight → Overweight 2026-08-19 43% win rate (7 calls)
Jones Trading - Reiterated
Buy → Buy 2026-08-13 57% win rate (14 calls)
Wells Fargo - Reiterated
Overweight → Overweight 2026-08-12 Building track record
HC Wainwright & Co. - Reiterated
Buy → Buy 2026-08-12 31% win rate (48 calls)
Guggenheim - Reiterated
Buy → Buy 2026-08-11 62% win rate (8 calls)
Guggenheim - Reiterated
Buy → Buy 2026-07-01 62% win rate (8 calls)
HISTORICAL SNAPSHOT

Point-in-time data from StockUpside's daily snapshots. Tracks price, analyst target, upside %, consensus, and analyst count.

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ANALYST CONVICTION SCORE
67
out of 100
Coverage depth
18/30
Consensus clarity
22/30
Vote unanimity
25/25
Rating stability
2/15

Measures analyst agreement, not fundamental quality. A high score means analysts broadly agree on this call - not that the stock will go up.

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