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Ranked #2457 by analyst upside · 2026-08-14
SEPN
Septerna, Inc.
Healthcare · Market Cap $2B · P/E 0x
ANALYST PRICE TARGET
+17.7%
implied upside to consensus target
Current Price $45.14
Consensus Target $53.11
Bull Target $62.0
Bear Target $38.0
Analysts Covering 9
ANALYST CONSENSUS - BUY
Strong Buy
1
Buy
8
Hold
0
Sell
0
52-Week Low $10.74
52-Week High $51.1
YTD Return +61.3%
FUNDAMENTALS
Market Cap $2B
P/E Ratio (TTM) N/A
Forward P/E N/A
EPS (TTM) $-0.53
PEG Ratio N/A
Dividend Yield N/A
Revenue (TTM) $99M
Profit Margin -24.5%
52-WEEK RANGE
52-Week Low $10.74
52-Week High $51.1
Current Price $45.14
Bear Target $38.0
Bull Target $62.0
● Now $45.14 ● Target $53.11
TRADING DATA
Avg Volume 430K
YTD Return +61.3%
Analyst Count 9
Consensus Buy
Upside to Target +17.7%
Last Updated 2026-08-14

ANALYST SUMMARY

Septerna, Inc. (SEPN) is currently trading at $45.14 with a Wall Street consensus price target of $53.11, implying potential upside of 17.7% over the next 12 months. 9 analysts currently cover SEPN, with a consensus rating of Buy - 100% of analysts rate the stock a Buy or Strong Buy. The most bullish analyst has a price target of $62.0, while the most cautious has a target of $38.0.

SEPN operates in the Healthcare sector with a market capitalisation of $2B. The stock is up 61.3% year-to-date and is currently trading near the upper end of its 52-week range of $10.74 – $51.1.

SIMILAR STOCKS

Other Healthcare stocks with comparable size and valuation.

RECENT ANALYST CALLS

Upgrade/downgrade history for SEPN, with each firm's 90-day track record across all stocks we track. See full firm rankings →

Raymond James - Reiterated
Strong Buy → Strong Buy 2026-06-08 Building track record
HC Wainwright & Co. reit
Buy → Buy 2026-05-13 31% win rate (48 calls)
HC Wainwright & Co. reit
Buy → Buy 2026-04-14 31% win rate (48 calls)
JP Morgan - Reiterated
Overweight → Overweight 2026-03-24 43% win rate (7 calls)
Truist Securities - Reiterated
Buy → Buy 2026-03-11 Building track record
Wells Fargo - Reiterated
Overweight → Overweight 2026-03-03 Building track record
HC Wainwright & Co. - Reiterated
Buy → Buy 2026-03-02 31% win rate (48 calls)
HC Wainwright & Co. - Reiterated
Buy → Buy 2026-01-20 31% win rate (48 calls)
HISTORICAL SNAPSHOT

Point-in-time data from StockUpside's daily snapshots. Tracks price, analyst target, upside %, consensus, and analyst count.

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ANALYST CONVICTION SCORE
64
out of 100
Coverage depth
18/30
Consensus clarity
19/30
Vote unanimity
25/25
Rating stability
2/15

Measures analyst agreement, not fundamental quality. A high score means analysts broadly agree on this call - not that the stock will go up.

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